Pyrimidine nucleosides
Apexbio Technology LLC 5-Ethynyl-2'-deoxyuridine (5-EdU), 1g CAS# 61135-33-9
5-Ethynyl-2'-deoxyuridine (5-EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. 5-EdU can be used as a replacement for BrdU (5-Bromo-2'-deoxyuridine) to measure de novo DNA synthesis during the S-phase of the cell cycle through click chemistry. Click chemistry is a method of covalently coupling an azide with an alkyne. 5-EdU has an alkyne handle that can be detected using azide-containing fluorescent probes through a highly efficient click chemistry reaction. In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-EdU-labelled cells may be isolated to determine the transcript of cells, from neural cancer or tissues that have undergone division in vitro and in vivo. Other sizes are also available. Please inqury us for quote.
Medchemexpress LLC KTX-951 | 2573298-36-7 | 99.6% | 850.95 | 1 MG
KTX-951 is an orally active PROTAC degrader targeting IRAK4 and IMiD (Ikaros/Aiolos) substrates. It exhibits a Kd of 3.5 nM for IRAK4, with DC50 values of 13 nM, 14 nM, and 13 nM for IRAK4, Ikaros, and Aiolos, respectively. This compound also shows an IC50 of 35 nM for OCl-Ly10 CTG and demonstrates antitumor activity.
- Orally active PROTAC degrader
- Targets IRAK4 and IMiD (Ikaros/Aiolos) substrates
- Kd of 3.5 nM for IRAK4
- Molecular weight: 850.95
- Formula: C46H52F2N8O6
- Appearance: Solid, light yellow to yellow
- Purity: 99.60%
- Soluble in DMSO at 50 mg/mL (58.76 mM)
- Oral bioavailability in rats: 22% at 10 mg/kg
- Oral bioavailability in dogs: 57% at 10 mg/kg
Medchemexpress LLC 2'-Deoxycytidine | 951-77-9 | 99.95% | 1 ML
2'-Deoxycytidine is a deoxyribonucleoside that can inhibit the biological effects of Bromodeoxyuridine (Brdu). It is essential for the synthesis of nucleic acids and can be used for cancer research.
- Inhibits biological effects of Bromodeoxyuridine (Brdu)
- Essential for nucleic acid synthesis
- Can be used for cancer research
- Intended for research use only
Medchemexpress LLC 2'-deoxyuridine-1′-13C | 478510-85-9 | 99.5% | 10 MG
2'-Deoxyuridine-1′-13C is a 13C-labeled isotopologue of 2'-deoxyuridine supplied as a research reagent and analytical standard for metabolite and isotope-labeling studies. It is provided as a powder with high chemical purity and defined storage recommendations.
![Medchemexpress LLC Deoxycytidine triphosphate-15N3 (dilithium) | 2056-98-6 | MFCD00135938 | 99.0% | 482.00 g·mol⁻1 | C9H14[15N]3Li2O13P3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211147.png-250.jpg)
Medchemexpress LLC Deoxycytidine triphosphate-15N3 (dilithium) | 2056-98-6 | MFCD00135938 | 99.0% | 482.00 g·mol⁻1 | C9H14[15N]3Li2O13P3 | 1 MG
Deoxycytidine triphosphate-15N3 (dilithium) is a stable isotope-labeled deoxynucleoside triphosphate provided as a concentrated aqueous solution for molecular biology and analytical applications. The 15N3 label enables sensitive and specific detection in mass spectrometry and tracer experiments, while the dilithium salt formulation offers good aqueous solubility. Typical uses include use as an internal standard, tracer, or reagent in DNA synthesis and sequencing workflows.
- Supplied as a concentrated solution for convenient dilution and use.
- 15N3 isotopic label supports quantitative mass spectrometry and tracer studies.
- High chemical purity for reliable analytical and preparative performance.
- Suitable as an internal standard or tracer in nucleic acid workflows.
- Compatible with PCR, cDNA synthesis, and DNA sequencing applications.
- Dilithium salt form improves solubility in aqueous buffers.
Medchemexpress LLC 2′-deoxycytidine-5′-triphosphate dilithium salt | 2687960-70-7 | 95.7% | 493.11 g/mol | C9D14Li2N3O13P3 | 5 MG
Deuterium-labeled deoxycytidine triphosphate in dilithium form supplied for use as an isotopic internal standard and tracer in analytical and biochemical workflows. It is intended for applications requiring an isotopically labeled nucleotide reference such as mass spectrometry, quantitative assays, and tracer studies.
- Deuterium-labeled nucleotide for isotopic tracing.
- Provided as a dilithium salt, compatible with common solvents.
- High purity suitable for analytical use (e.g., ~95.7%).
- Molecular weight 493.11 g/mol; formula C9D14Li2N3O13P3.
- Useful as an internal standard for mass spectrometry and quantitative assays.
- Store according to supplier recommendations to maintain stability.
Medchemexpress LLC Deoxycytidine triphosphate | 2056-98-6 | MFCD00135938 | 98.2% | 467.16 g/mol | C9H16N3O13P3 | 50 MG
Deoxycytidine triphosphate (dCTP) is a deoxynucleoside triphosphate used as a substrate for DNA polymerases in molecular biology. Supplied as a laboratory reagent, it is intended for enzymatic DNA synthesis applications such as PCR, cDNA synthesis, and DNA sequencing.
- High purity suitable for enzymatic DNA synthesis and PCR.
- Accurate molecular weight and formula for reagent planning.
- Supplied in a convenient small-scale package for method development.
- Stable when stored under recommended conditions to preserve activity.
- Commonly used as a deoxynucleotide substrate in sequencing and amplification workflows.
Bioworld 5-Bromo-2'-deoxyuridine, 5 g
It is a thymidine analogue which is incorporated into DNA. 5-BrdU is routinely and extensively used to measure DNA synthesis and to label dividing cells. Consequently 5-BrdU is used to study cell signaling and other processes that induce cell proliferation. Thymidine analog used for study of DNA synthesis. This analog selectively incorporates into cellular DNA during S-phase.Appearance: White powder.ChEBI : Not available.Crystal_Structure : Not available.InChI : Not available.InChIKey : Not available.Melting Point: 191-194 °C (dec.)(lit.)
Bioworld 2'-Deoxythymidine, 25 g
It is a pyrimidine deoxynucleoside.It is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA.It can be phosphorylated with one, two or three phosphoric acid groups, creating respectively deoxythymidine mono,di or triphosphate.It is non-toxic and as part of one of the four nucleotides in DNA it is a naturally occurring compound that exists in all living organisms and DNA viruses. Specifications:Ultra Pure GradeEm (267nm, phosphate buffer, pH 7.0): >9,200Appearance: White Crystalline PowderChEBI : Not available.Crystal_Structure : Not available.Density : 1.452 g/cm3InChI : Not available.InChIKey : Not available.IUPAC_Name: 1-[4-Hydroxy-5-(Hydroxymethyl)Oxolan-2-Yl]-5-Methyl-Pyrimidine-2,4-DioneMelting Point: 186-188 °C(lit.)RTECS Number: XP2071000
Cambridge Isotope Laboratories 2-Fluoro-2-deoxyuridine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 90% 100 umol
2-Fluoro-2-deoxyuridine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 90% 100 umol
Cayman Chemical 5-Chloro-2-deoxyurIdIn 25mg
A thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine; can be detected immunologically in cells and tissues
Medchemexpress LLC HY-D0186 100mg Medchemexpress, 2'-Deoxyuridine CAS:951-78-0 Purity:>98%
Medchemexpress, HY-D0186 100mg 2'-Deoxyuridine CAS:951-78-0 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.